"Rational Design of DNA Machines"
Dr. Niles A. Pierce
California Institute of Technology
Friday, May 6, 2005
Single-stranded DNA is a versatile construction material that can be
programmed to self-assemble into nanoscale devices driven by the free
energy of base pair formation. Rational sequence design methods based on
efficient partition function algorithms permit simultaneous optimization of
affinity and specificity for target secondary structures that define the
function of a device. These methods have been used to engineer a synthetic
DNA walker that mimics the gait of kinesin and a class of biosensors based
on the mechanism of hybridization chain reaction.
Host: Bruce Tidor
Contact: Brenda Pepe, 617-452-3885
Sponsored by CSBi
Annual CSBi Seminar Series in Computational and Systems Biology