May 27th, 2009

Anhinga, snakebird

Anti-angiogenesis drugs :-(

I still remember time when great hopes in anti-cancer therapy were raised in connection with drugs blocking formation of new blood vessels. And (as it is often the case) the results in mice were great.Then the hopes dimmed, and the controversial approval of Avastin by FDA in 2008 against the recommendation of its advisory panel underscored the fact that the advances were quite marginal (the panel objected because for that class of tumors Avastin only slowed tumor growth but failed to extend survival):

http://en.wikipedia.org/wiki/Bevacizumab

Here is an article which seems to shed some light on why the "magic bullet" does not quite work:

http://scienceblog.cancerresearchuk.org/2009/03/22/anti-angiogenesis-drugs/

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